Erler Lab, May 2017 

Kræftens Bekæmpelse, the Danish Cancer Society, has awarded a 3-year postdoctoral fellowship to our newest member, Sebastian Rune Nielsen, to determine how the extracellular matrix regulates the function of tumour-associated macrophages in pancreatic cancer.

Patients with pancreatic cancer have the worst prognosis among all cancer patients, with only 7% of patients alive 5 years after their diagnosis. In 2030, pancreatic cancer is predicted to be the second most common cause of death among cancer patients. There is an urgent need to improve the therapeutic options for patients, as the survival rate has not improved in the last 10 years.

Already we know that the presence of tumour-associated macrophages in the pancreatic tumour correlates with decreased patient survival. In addition, the composition of extracellular matrix proteins, and the stiffness of tumour tissue, change as the tumour grows and the cancer progresses. The goal of this project is to determine how changes in the extracellular matrix, such as altered protein composition and increased tissue rigidity, regulate the function of tumour-associated macrophages in pancreatic cancer. The ultimate aim is to identify new tumour-promoting signalling pathways in tumour-associated macrophages that can be targeted therapeutically to block tumour progression in pancreatic cancer.

We are grateful to Kræftens Bekæmpelse for their support in this project. You can learn more about Kræftens Bekæmpelse by visiting their website: www.cancer.dk

By Erler Lab, April 2017

We are looking for a highly motivated and dynamic student, with a strong interest in the tumour microenvironment.

Project
The student will research how the extracellular matrix is altered during cancer progression. The project will include novel therapeutic targeting strategies to disrupt metastasis.

Start: Preferably 1^st September 2017 or after agreement.

Duration: 3 years as a PhD

Qualifications
We are looking for a highly motivated and enthusiastic candidate with the following qualifications:

• A Master of Science in biology, biochemistry or similar
• Experience in cancer research
• Knowledge about the tumour microenvironment
• Knowledge about the extracellular matrix
• Excellent communication skills in English To be considered for the position as PhD fellow, it is a condition, that your Master of Science degree is considered to be equivalent to a Danish Master of Science (http://fivu.dk/en). For further information regarding the position, please contact Associate Professor Janine Erler on e-mail: janine.erler@bric.ku.dk

Application
Your application must be submitted electronically via BRIC’s website on http://www.bric.ku.dk/jobs/.

Raphael Reuten, March 2017

The German Society for Matrix Biology Young Investigator Award is selected every year during the society’s Annual Meeting. This year the meeting took place in Cologne and was organised by Gerhard Sengle, Julia Etich and others.

I was delighted to be nominated, together with two other outstanding scientists: Eva Brauchle, from the  Schenke-Layland lab, University of Tübingen and the Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB) and Zhiqi Sun, from the Fässler lab, Max-Planck Institute of Biochemistry, Matrinsried, Munich).

Eva Brauchle presented an interesting and promising diagnostic tool which uses spectroscopy to detect deficiencies of extracellular matrix proteins related with skin diseases while Zhiqi Sun presented the uncoupling role of the intracellular Kank protein family members of integrins, during force transduction.

I was excited to present parts of my PhD thesis, giving insight into the disruptive force of the secreted extracellular matrix protein netrin-4 on basement membranes (read more about my work), and was thrilled to be selected as the winner of the Young Investigator Award.

The Annual Meeting of the German Matrix Society brings the majority of german matrix experts together every year. Moreover, the Society aims to invite outstanding scientists working on extracellular matrix topics and problems. This year we had the chance to see the work of Vivek Malhotra, Barcelona, Spain who provided insight into Collagen secretion; Viola Vogel, Zurich, Switzerland who presented a peptide approach to sense matrix stiffness status within tissues, and Boris Hinz, Toronto, Canada who showed the memory ability of fibrotic matrix.

I would like to thank the whole organising team of the Meeting for some inspiring days.

Cancer patient survival rates in Denmark are among the poorest in Europe, but a new project aims to use personalized medicine to fight back. A number of public and private partners have come together to treat cancer patients with much better accuracy than before, by using patients’ own cells to identify the best possible treatment.

The spread of cancer from a primary tumor to other parts of the body is called metastasis. Metastasis is very complex and often patients with the same type of cancer do not respond to treatment in the same way. This new project, will establish a precision medicine approach to identifying effective treatment options for individual cancer patients with metastatic cancer and involves an already established clinical program at Rigshospitalet where patient tumors are being molecularly profiled.

This ‘pre-clinical program for cancer precision medicine’ will enable pre-screening of drugs to identify the optimal treatment strategy for each patient, using cells from patients grown in the laboratory and tested with a range of potential anti-cancer drugs. Through the use of patient-derived cells, along with the profiling data to create a personalized treatment strategy, the team is also hopeful they will create a platform for future development of new and targeted drugs in collaboration with pharmaceutical companies.

“With this grant from Innovationsfonden we now have the opportunity to accurately match patients with the treatment option that has the best chance of stopping their cancer in its tracks. For too many patients, treatment for metastatic cancer is not effective yet the side-effects can be devastating. We are extremely excited about the opportunity to bring patients the most effective treatment, and to learn much more about why some medicines work in some but not all situations”, says Janine Erler, Professor at the Biotech Research & Innovation Centre (BRIC), University of Copenhagen.

The project, which will be based at BRIC and Rigshospitalet, is in close collaboration with the pharmaceutical companies AstraZeneca, Roche A/S and MSD. BRIC contributes with extensive expertise within the field of metastasis, while the Rigshospitalet team has wide-ranging knowledge and experience in translating findings directly into the clinic to the patients who matter. The pharmaceutical partners contribute their access to a wide catalogue of anti-cancer medications, and their lengthy experience in research and innovation.

Erlerlab Nov 2016

We have been awarded a Pre-Seed grant by the Novo Nordisk Foundation

The majority of cancer deaths are caused when a primary cancer spreads to different parts of the body, so for a long time we have been interested in preventing this spread (called metastasis). The Novo Nordisk Foundation pre-seed grants are exploratory funds to develop new and life-saving technologies, and the foundation has awarded us a grant to develop new anti-metastatic therapies.

This exciting project means we’ll be recruiting a talented postdoc to join our team. If you’d like to know more information at this early stage, please get in touch (janine.erler@bric.ku.dk)

Erler Lab, Oct 2016

Kræftens Bekæmpelse, the Danish Cancer Society, has awarded us a new grant to personalise the treatments for patients suffering with relapsed glioblastoma (brain tumours) in Denmark. This grant comes under the Knæk Cancer (or ‘Break Cancer’) campaign.

Glioblastoma can vary greatly, so it is important to understand how each individual tumour will respond to different treatments. The aim of this project is to analyse patient samples with a range of tests in the laboratory, to discover the best possible treatment for each unique patient. Similar systems are in place in other countries, however this currently doesn’t exist in Denmark, so we are hopeful that this project will have a big impact on the lives of those fighting brain cancer.

We are grateful to Kræftens Bekæmpelse for their support in this project. You can learn more about Kræftens Bekæmpelse by visiting their website: www.cancer.dk/

Janine Erler, Sept 2016

This week we are saying fond farewells to Dr Tom Cox, who has been part of the Erler group for eight and a half years!

Tom was the second person I hired when I set up my own research group. He joined my lab in May 2008 following his PhD, while we were at the Institute of Cancer Research in London. He moved over to BRIC with me in 2012, and has been my right hand man through all the years. During his time in the lab, Tom has contributed to no fewer than 25 peer reviewed publications and has delivered talks to share our research at nearly 20 conferences.

Over the years Tom has been part of some funny, poignant and downright ludicrous moments, including his foray into professional modelling, when he was featured (twice) in Vogue UK.

Tom has made some fantastic discoveries during his time in the group, including insight into how tumours prepare distant sites for metastatic colonisation.

Other memorable moments include when Tom broke his ankle dancing a Ceilidh 🙂

Although we will miss his sharp observations, his witty jokes, and his ability to reach things on high shelves, we are all really pleased that he is heading to sunny Sydney to establish an independent research career at the Garvan Institute. Personally, I will be losing a limb but I will hobble on somehow!

Wishing you all the very best for the future Tom, and please don’t forget to come and visit us once in a while!

Erler Lab, Sept 2016

We are delighted to welcome a new postdoctoral researcher to our group. Please put your hands together for Dr Raphael Reuten.

Raphael is joining us from Germany, and brings his expertise in the Extracellular Matrix (ECM) to help us to understand even more about how the structures around our cells play a role in the progression of cancer. Raphael completed his PhD at the University of Cologne in the lab of Univ.-Prof. Dr. Manuel Koch and has continued his studies in the field of matrix biology ever since.

We are looking forward to making some exciting progress together.

Erler Lab, August 2016

Sadly, we are saying a big farewell to Dr Lara Perryman, who is leaving us today after four years in the Erler lab.

Lara joined us in 2012 to complete her PhD, after gaining years of research experience working with Prof Chris Jones at the ICR. She finished her PhD last year, and continued working in our group as a postdoctoral research assistant. Among her many findings, Lara’s research into brain cancer has revealed a novel mechanism of glioblastoma invasion. Her brilliant expertise and her invaluable contributions to everyone’s projects will be sorely missed.

Although we’re really sad to see Lara go, she’s returning to her native Australia to begin an exciting new chapter working at Pharmaxis.

Wishing you all the very best for the future Lara, and watch out for all the spiders and snakes down under!

By Erler Lab, July 2016

We are looking for a highly motivated and dynamic researcher, with specific skills to undertake research into how the extracellular matrix regulates cancer progression.

Project
The postdoc will investigate how the extracellular matrix regulates cancer cell behaviour, using multiphoton microscopy to image cell-matrix and cell-cell interactions both ex vivo and in vivo.

Start: Preferably 1^st October 2016 or after agreement
Duration: 4 years

The project is supported by an ERC programme grant. For more information, check the University of Copenhagen Job Portal or contact Janine by emailing janine.erler@bric.ku.dk