
Acronym: MATRICAN
Grant number: ERC-2015-CoG-682881-MATRICAN
Short description
The extracellular matrix (ECM) is known to play a critical role in driving cancer progression, and yet we lack knowledge of its composition and structure. The goal of my ERC project is to investigate how alterations in biochemical composition and structural properties of the ECM during cancer progression impact on cell behaviour to drive metastasis, which is responsible for over 90% of cancer patient deaths. The research proposed will provide ground breaking insight into how the ECM regulates cellular behaviour during normal and pathological conditions, and will test new strategies to combat metastasis that could be translated into the clinic to benefit cancer patients.
Publications
Mayorca, Madsen, Cox et al, 2017, Nature Medicine (link)
Mayorca, Willacy et al, 2019, Nature Protocols (link)
Team
Janine Erler (PI)
Alejandro Mayorca Guiliani (Assistant Professor)
Adina Jensen (PhD student)
Jan Strøbech (PhD Student)
Anna Leibold (Student Helper)