Post-doctoral training fellows
Alejandro Mayorca Guiliani
My interest is in the physical structure of a tissue that influences the behaviour of the cells who reside in it. I have developed a method to determine tissue structure at the nanometre scale. Now we are studying the structure of early and advanced tumours, looking for new strategies to steer structural influence towards disease resolution.
My research focuses on investigating the roles of stromal HIF prolyl 4-hydroxylases in mediating tumour growth and extracellular matrix (ECM) remodelling to drive cancer progression.
Edward R Horton
Kamilla Westarp Zornhagen
During my PhD I studied the tumour microenvironment and its heterogeneity in spontaneous canine soft tissue sarcomas using different molecular markers. Now my research is focused on the extracellular matrix (ECM) and how it affects metastasis.
During my PhD I extensively studied the functional role of the laminin network during angiogenesis and cancer progression. My current research focuses on the influence of the ECM on cancer and endothelial cell invasion. The goal of my projects is to unravel novel extracellular targets to alter cell invasion. Read more on my LinkedIn profile.
Sebastian Rune Nielsen
During my PhD, I demonstrated a crucial role of metastasis-associated macrophages in orchestrating the formation of a hospitable metastatic niche in the liver after dissemination of pancreatic cancer cells. My current focus is to understand how macrophage function is regulated by changes in ECM composition and structure during tumor development and metastasis.
I am fascinated by how different tissues are constructed and how cancer semmingly metastasizes differently to these tissues. My project aims to engineer vascular networks and ECM-mimicking materials into in vitro models of different tissues. The hope is that it will provide an assay that can determine to which tissues an individual patient’s cancer is most likely to metastasize.
I am interested in the way in which the tumour microenvironment influences the metastases and progression of cancer. My PhD will focus on the study of normal fibroblasts as compared to cancer associated fibroblasts using both in vivo and in vitro models, with specific interest in the function and role of the PHD proteins (prolyl hydroxylase domain-containing).
I am interested in the composition of the stromal compartment of the tumour microenvironment, and how different stromal cells such as fibroblasts impact the tumour progression and metastasis. In my PhD project I am combining my research into this with my passion for visualising biological processes by using different microscopy techniques, including multi-photon intravital imaging.
My long term goal is to uncover the molecular mechanisms regulating cancer cell dissemination through the body. In the PhD project I am studying how the extracellular matrix in different sites of primary tumour growth is influencing the metastatic potential of the cancer cells. I am working with a variety of cancer models applying a broad spectrum of molecular methods to investigate ECM composition and its effects on gene expression and cell signaling in cancer cells.
I want to explore what happens within stromal tissue during metastasis, in particular how the tumour microenvironment promotes cancer progression. My PhD focuses on changes in cell populations during metastatic disease and how stromal cells contribute to changes in the ECM. I will apply single cell RNA sequencing to explore this area.
I am a molecular biomedicine student and I am part of the established PreCan project. This project aims to identify effective therapeutic strategies for the treatment of individual cancer patients with metastatic solid tumors.
I study Human Biology and for my thesis I focus on how cells change their binding behavior when they were previously exposed to ECM proteins. I am also interested in changes of metastatic activities of tumor cells when exposed to different drugs.
Technical support staff
Jesper Thorhauge Pedersen
Lukram Babloo Singh
Marc Garcia Montolio
Peter Bavngaard Thrane
Sofie Dahl Tolstrup
Tine Thurison Røndbjerg