Select Papers
2022
Modeling Metastatic Colonization in a Decellularized Organ Scaffold‐Based Perfusion Bioreactor
Maria Rafaeva, Edward R. Horton, Adina R.D. Jensen, Chris D. Madsen, Raphael Reuten, Oliver Willacy, Christian B. Brøchner, Thomas H. Jensen, Kamilla Westarp Zornhagen, Marina Crespo, Dina S. Grønseth, Sebastian R. Nielsen, Manja Idorn, Per thor Straten, Kristoffer Rohrberg, Iben Spanggaard, Martin Højgaard,U lrik Lassen, Janine T. Erler, and Alejandro E. Mayorca-Guiliani
Advanced Healthcare Materials, 11(1), p.2270001. https://doi.org/10.1002/adhm.202270001
2021
Organ-Specific, Fibroblast-Derived Matrix as a Tool for Studying Breast Cancer Metastasis
Adina R. D. Jensen , Edward R. Horton , Lene H. Blicher , Elin J. Pietras , Cornelia Steinhauer , Raphael Reuten , Erwin M. Schoof and Janine T. Erler
Cancers 2021, 13(13), 3331; https://doi.org/10.3390/cancers13133331
Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade
Sebastian R. Nielsen , Jan E. Strøbech, Edward R. Horton, Rene Jackstadt, Anu Laitala, Marina C. Bravo, Giorgia Maltese, Adina R. D. Jensen, Raphael Reuten, Maria Rafaeva, Saadia A. Karim, Chang-Il Hwang, Luis Arnes, David A. Tuveson, Owen J. Sansom, Jennifer P. Morton & Janine T. Erler
Nat Commun 12, 3414 (2021). https://doi.org/10.1038/s41467-021-23731-7
Netrin-4 regulates stifness and metastasis (News & Views)
Patrick Mehlen & Laurent Fattet
Nat. Mater. 20, 722–723 (2021). https://doi.org/10.1038/s41563-021-01012-4
Decellularization of the Murine Cardiopulmonary Complex
Alejandro E. Mayorca-Guiliani, Maria Rafaeva, Oliver Willacy, Chris D. Madsen, Raphael Reuten, Janine T. Erler
J. Vis. Exp. (171), e61854, doi:10.3791/61854
Deciphering the temporal heterogeneity of cancer-associated fibroblast subpopulations in breast cancer
Freja Albjerg Venning, Kamilla Westarp Zornhagen, Lena Wullkopf, Jonas Sjölund, Carmen Rodriguez-Cupello, Pontus Kjellman, Mikkel Morsing, Morteza Chalabi Hajkarim, Kyoung Jae Won, Janine Terra Erler & Chris Denis Madsen
Journal of Experimental & Clinical Cancer Research https://doi.org/10.1186/s13046-021-01944-4
Basement membrane stiffness determines metastases formation
Raphael Reuten, Sina Zendehroud, Monica Nicolau, Lutz Fleischhauer, Anu Laitala, Stefanie Kiderlen, Denise Nikodemus, Lena Wullkopf, Sebastian Rune Nielsen, Sarah McNeilly, Carina Prein, Maria Rafaeva, Erwin M. Schoof, Benjamin Furtwängler, Bo T. Porse, Hyobin Kim, Kyoung Jae Won, Stefanie Sudhop, Kamilla Westarp Zornhagen, Frank Suhr, Eleni Maniati, Oliver M. T. Pearce, Manuel Koch, Lene Broeng Oddershede, Tom Van Agtmael, Chris D. Madsen, Alejandro E. Mayorca-Guiliani, Wilhelm Bloch, Roland R. Netz, Hauke Clausen-Schaumann & Janine T. Erler
Nature Materials doi.org/10.1038/s41563-020-00894-0
2020
2019
2018
Cancer cell ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential
Molecular Biology of the Cell doi.org/10.1091/mbc.E18-05-0319
Tumor endothelial marker 8 promotes cancer progression and metastasis
Oncotarget 9(53):30173-30188 doi.org/10.18632/oncotarget.25734
Notch‐inducing hydrogels reveal a perivascular switch of mesenchymal stem cell fate
Martin I, Snedeker JG, Milleret V, Ehrbar M
EMBO Reports 19(8):e45964 doi:
Friction-limited cell motility in confluent monolayer tissue
Christensen A, West AV, Wullkopf L, Erler JT, Oddershede LB, Mathiesen J
Phys Biol pubmed:29939152
Hypoxic signalling in tumour stroma
Laitala A, Erler JT
Frontiers in Oncology 8:189 pubmed:29896451
Proteomic characterisation of caenorhabditis elegans larval development
Xia T, Horton ER, Salcini AE, Pocock R, Cox TR, Erler JT
Proteomics 18(2) pubmed:29178193
2017
Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer as an example
Fingleton B, Lange K, Caldwell B, Bankaitis KV; Board of the Metastasis Research Society
Clinical & Experimental Metastasis 34(8):443-447 pubmed:29484519
Established models and new paradigms for hypoxia-driven cancer-associated bone disease
Cox TR, Erler JT, Rumney RMH
Calcif Tissue Int pubmed:29098360
Dynamic rearrangement of cell states detected by systematic screening of sequential anticancer treatments
Koplev S, Longden J, Ferkinghoff-Borg J, Blicher Bjerregård M, Cox TR, Erler JT, Pedersen JT, Voellmy F, Sommer MOA, Linding R
Cell Rep 20(12):2784-2791 pubmed:28930675
ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix
Mayorca-Guiliani AE, Madsen CD, Cox TR, Horton ER, Venning FA, Erler JT
Nat Med 23(7):890-898 pubmed:28604702
Pre-metastatic niches: organ-specific homes for metastases
Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, Bissell MJ, Cox TR, Giaccia AJ, Erler JT, Hiratsuka S, Ghajar CM, Lyden D
Nat Rev Cancer 17(5):302-317 pubmed:28303905
Correlation of ultrasound shear wave elastography with pathological analysis in a xenografic tumour model
Elyas E, Papaevangelou E, Alles EJ, Erler JT, Cox TR, Robinson SP, Bamber JC
Sci Rep 7(1):165 pubmed:28279018
Dynamics of cancerous tissue correlates with invasiveness
West AV, Wullkopf L, Christensen A, Leijnse N, Tarp JM, Mathiesen J, Erler JT, Oddershede LB
Sci Rep 7:43800 pubmed:28262796
Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer
Chang J, Lucas MC, Leonte LE, Garcia-Montolio M, Singh LB, Findlay AD, Deodhar M, Foot JS, Jarolimek W, Timpson P, Erler JT, Cox TR
Oncotarget 8(16):26066-26078 pubmed:28199967
Multi-channel optical coherence elastography using relative and absolute shear-wave time of flight
Elyas E, Grimwood A, Erler JT, Robinson SP, Cox TR, Woods D, Clowes P, De Luca R, Marinozzi F, Fromageau J, Bamber JC
PLoS One 12(1):e0169664 pubmed:28107368
2016
The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis
Gartland A, Erler JT, Cox TR
J Bone Oncol 5(3):100-103 pubmed:27761366
Fibrosis and cancer: partners in crime or opposing forces?
Cox TR. Erler JT
Trends In Cancer cell:S2405-8033
Structural ECM components in the premetastatic and metastatic niche
Høye AM, Erler JT
Am J Physiol Cell Physiol 310(11) pubmed:27053524
Comparison of 18F-FET and 18F-FLT small animal PET for the assessment of anti-VEGF treatment response in an orthotopic model of glioblastoma
Nedergaard MK, Michaelsen SR, Perryman L, Erler JT, Poulsen HS, Stockhausen M-T, Lassen U, Kjaer A
Nucl Med Biol 43(3) 198-205 pubmed:26924500
Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients
Liu N, Cox TR, Cui W, Adell G, Holmlund B, Ping J, Jarlsfelt I, Erler JT, Sun XF
Oncotarget pubmed:27231855
Lysyl oxidase, a targetable secreted molecule involved in cancer metastasis
Cox TR, Gartland A, Erler JT
Cancer Research 76(2):188-92 pubmed:26732355
Matrix cross-linking lysyl oxidases are induced in response to myocardial infarction and promote cardiac dysfunction
González-Santamaría J, Villalba M, Busnadiego O, López-Olañeta MM, Sandoval P, Snabel J, López-Cabrera M, Erler JT, Hanemaaijer R, Lara-Pezzi E, Rodríguez-Pascual F
Cardiovasc Res 109(1):67-78 pubmed:26260798
2015
VEGF-C contributes to autocrine VEGFR2 signaling and affects cell viability and tumour growth in glioblastoma
Michaelsen SR, Nedergaard MK, Urup T, Villingshoej M, Kjaer A, Perryman L, Erler JT, Lassen U, Poulsen HS
Neuro-Oncology 17:v41-v44 neuro.doi:10.1093
Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism
Cox TR, Schoof EM, Gartland A, Erler JT, Linding R
Data Brief 5:621-625 pubmed:26649326
Targeting ECM disrupts cancer progression
Venning FA, Wullkopf L, Erler JT
Front Oncol 5:224 pubmed:26539408
Pten regulates epithelial cytodifferentiation during prostate development
Lokody IB, Francis JC, Gardiner JR, Erler JT, Swain A
PLoS One 10(6):e0129470 pubmed:26076167
Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy
Miller BW, Morton JP, Pinese M, Saturno G, Jamieson NB, McGhee E, Timpson P, Leach J, McGarry L, Shanks E, Bailey P, Chang D, Oien K, Karim S, Au A, Steele C, Carter CR, McKay C, Anderson K, Evans TR, Marais R, Springer C, Biankin A, Erler JT, Sansom OJ
EMBO Mol Med 7(8):1063-76 pubmed:26077591
Kinome-wide decoding of network attacking mutations rewiring cancer
Creixell P, Schoof EM, Simpson CD, Longden J, Miller CJ, Lou HJ, Perryman L, Cox TR, Zivanovic N, Palmeri A, Wesolowska-Andersen A, Helmer-Citterich M, Ferkinghoff-Borg J, Itamochi H, Bodenmiller B, Erler JT, Turk BE, Linding R
Cell 163(1):202-217 pubmed:26388441
Interdisciplinary research: bold alliances aid translational work
Erler JT
Nature 517(7535):438. pubmed:25612042
Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis
Madsen CD, Pedersen JT, Venning FA, Singh LB, Moeendarbary E, Charras G, Cox TR, Sahai E, Erler JT
EMBO Rep 16(10):1394-1408 pubmed:26323721
Stimulating translational research: several European life science institutions put their heads together
Bentires-Alj M, Rajan A, van Harten W, van Luenen HG, Kubicek S, Andersen JB, Saarela J, Cook SJ, Van Minnebruggen G, Roman-Roman S, Maurer C, Erler JT, Bertero MG
Trends Mol Med 21(9):525-527 pubmed:26254816
STRIPAK components determine mode of cancer cell migration and metastasis
Madsen CD, Hooper S, Tozluoglu M, Bruckbauer A, Fletcher G, Erler JT, Bates PA, Thompson B, Sahai E
Nat Cell Biol 17(1):68-80 pubmed:25531779
AGE‐modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival
Rodriguez‐Teja M, Gronau JH, Breit C, Zhang Y, Minamidate A, Caley MP, McCarthy A, Cox TR, Erler JT, Gaughan L, Darby S, Robson C, Mauri F, Waxman J, Sturge J
J Pathol 235(4):581-592 pubmed:25408555
2014
Fibrosis, cancer and the premetastatic niche
Cox TR, Erler JT
Breast Cancer Management 3(6):453-455 futuremedicine/10.2217
Lysyl oxidase in cancer research
Perryman L, Erler JT
Future Oncol 10(9):1709-1717 pubmed:25145437
Molecular pathways: connecting fibrosis and solid tumor metastasis
Cox TR, Erler JT
Clin Cancer Res 20(14):3637-3643 pubmed:25028505
Brain cancer spreads
Perryman L, Erler JT
Sci Transl Med 6(247):247fs28 pubmed:25080473
Lysyl oxidase in colorectal cancer
Cox TR, Erler JT
Am J Physiol Gastrointest Liver Physiol 305(10):G659-G666 pubmed:24008360
Ionizing radiation induces tumor cell lysyl oxidase secretion
Shen CJ, Sharma A, Vuong DV, Erler JT, Pruschy M, Broggini-Tenzer A
BMC Cancer 14:532 pubmed:25052686
Identification of hypoxia-regulated proteins using MALDI-mass spectrometry imaging combined with quantitative proteomics
Djidja MC, Chang J, Hadjiprocopis A, Schmich F, Sinclair J, Mršnik M, Schoof EM, Barker HE, Linding R, Jørgensen C, Erler JT
J Proteome Res 13(5):2297-313 pubmed:24702160
Cancer: Disabling defences in the brain
Erler JT
Nature 508(7494):46-47 pubmed:24695307
2013
LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling
Chang J, Nicolau MM, Cox TR, Wetterskog D, Martens JW, Barker HE, Erler JT
Breast Cancer Research 15(4):R67 pubmed:23971878
The potential for targeting extracellular LOX proteins in human malignancy
Mayorca-Guiliani A, Erler JT
Onco Targets Ther 6:1729-1735 pubmed:24348049
The importance of LOX family members on modulating cell-ECM interactions in carcinogenesis
Cox TR and Erler JT
J Carcinogene Mutagene S13:001 omicsonline/2157-2518.S13
LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis
Cox TR, Bird D, Baker AM, Barker HE, Ho MW, Lang G, Erler JT
Cancer Research 73(6):1721-1732 pubmed:23345161
Tumor-secreted LOXL2 activates fibroblasts through FAK signaling
Barker HE, Bird D, Lang G, Erler JT
Mol Cancer Res 11(11):1425-1436 pubmed:24008674
Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis
Baker AM, Bird D, Welti J, Gourlaouen M, Lang G, Murray G, Reynolds AR, Cox TR, Erler JT
Cancer Research 73(2):583-594 pubmed:23188504
2012
Network biology and the 3-Dimensional tumor micro-environment: personalizing medicine for the future
Cox TR, Erler JT
Tumor Microenvironment and Therapy (1):14-18 degruyter/2012-0002
The rationale for targeting the LOX family in cancer
Barker HE, Cox TR and Erler JT
Nature Reviews Cancer 12(8):540-552 pubmed:22810810
Navigating cancer network attractors for tumor-specific therapy
Creixell P, Schoof EM, Erler JT, Linding R
Nat Biotechnol 30(9):842-848 pubmed:22965061
The pre-metastatic niche: is metastasis random?
Cox TR, Gartland A, Erler JT
Bonekey Rep 1:80 pubmed:27127624
Contrasting effects of sunitinib within in vivo models of metastasis
Welti JC, Powles T, Foo S, Gourlaouen M, Preece N, Foster J, Frentzas S, Bird D, Sharpe K, van Weverwijk A, Robertson D, Soffe J, Erler JT, Pili R, Springer CJ, Mather SJ, Reynolds AR
Angiogenesis 15(4):623-641 pubmed:22843200
Network medicine strikes a blow against breast cancer
Erler JT, Linding R
Cell 149(4):731-733 pubmed:22579276
Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK
Baker AM, Lang G, Bird D, Cox TR, Erler JT
Oncogene 32(14):1863-1868 nature/2012202a
2011
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
Cox TR, Erler JT
Dis Model Mec 4(2):165-178 pubmed:21324931
The role of lysyl xxidase in SRC-dependent proliferation and metastasis of colorectal cancer
Baker A-M, Cox TR, Bird D, Lang G, Murray G, Sun X-F, Southall S, Wilson J, Erler JT
J Natl Cancer Inst 103(5):407-424 pubmed:21282564
The potential for LOXL2 as a target for future cancer treatment
Barker HE, Erler JT
Future Oncol 7(6):707-710 pubmed:21675833
LOXL2-mediated matrix remodeling in metastasis and mammary gland involution
Barker HE, Chang J, Cox TR, Lang G, Bird D, Nicolau M, Evans HR, Gartland A, Erler JT
Cancer Res 71(5):1561-1572 pubmed:21233336
2010
Network based drugs and biomarkers
Erler JT, Linding R
J Pathol 220(2):290-296 pubmed:19921715
Hypoxia in Models of Lung Cancer: Implications for Targeted Therapeutics
Graves EE, Vilalta M, Cecic I, Erler JT, Tran PT, Felsher D, Sayles L, Sweet-Cordero A, Le Q-T, Giaccia AJ
Clin Cancer Res 16(19):4843-4852 pubmed:20858837
Tissue section AFM: In situ ultrastructural imaging of native biomolecules
Graham HK, Hodson NW, Hoyland JA, Millward-Sadler SJ, Garrod D, Scothern A, Griffiths CE, Watson RE, Cox TR, Erler JT, Trafford AW, Sherratt MJ
Matrix Biol 29(4):254-260 pubmed:20144712
2009
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the pre-metastatic niche
Erler JT, Bennewith KL, Cox TR, Lang G, Bird D, Le Q-T, Koong A, Giaccia AJ
Cancer Cell 15(1):35-44 pubmed:19111879
Bioreductively activated lysyl oxidase inhibitors against hypoxic tumours
Granchi C, Funaioli T, Erler JT, Giaccia AJ, Macchia M, Minutolo F
ChemMedChem 4(10):1590-1594 pubmed:19685543
Matrix crosslinking forces tumor progression by enhancing integrin signaling
Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, Yamauchi M, Gasser DL, Weaver VM
Cell 139(5):891-906 pubmed:19931152
The role of Connective Tissue Growth Factor (CTGF/CCN2) in pancreatic tumor growth
Bennewith KL, Huang X, Ham C, Graves E, Erler JT, Kambham N, Giaccia AJ
Cancer Res 69(3):775-784 pubmed:19179545
Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03
Le QT, Harris J, Magliocco AM, Kong CS, Diaz R, Shin B, Cao H, Trotti A, Erler JT, Chung CH, Dicker A, Pajak TF, Giaccia AJ, Ang KK
J Clin Oncol 27(26):4281-4286 pubmed:19667273
The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth
Bennewith KL, Huang X, Ham CM, Graves EE, Erler JT, Kambham N, Feazell J, Yang GP, Koong A, Giaccia AJ
Cancer Res 69(3):775-784 pubmed:19179545
Three-dimensional context regulation of metastasis
Erler JT, Weaver VM
Clin Exp Metastasis 26(1):35-49 pubmed:18814043
Invited Book Chapters
Biomarkers of the tumor microenvironment: Basic studies and practical applications
El Rayes T, Gao D, Altorki N, Cox TR, Erler JT, Mittal V
(2016) Springer publications ISBN:978-3-319-39145-8
Quantification of lung metastases from in vivo mouse models. Tumour microenvironment and cellular stress
Chang J, Erler JT
(2015) Springer Publications ISBN:978-3-319-26664-0
Remodeling of the extracellular matrix, cell and molecular biology of breast cancer
Cox TR, Erler JT
(2013) Humana Press ISBN:978-1-62703-633-7
Hypoxia regulated metastasis, tumour microenvironment and cellular stress
Chang J, Erler JT
(2013) Springer Publications ISBN:978-1-4614-5914-9
Critical steps in cancer metastasis: Chapter 3 of Abeloff’s Clinical Oncology
Rankin EB, Erler JT, Giaccia AJ
(2013) Elsevier Publications
Pre-metastatic niches: Chapter 8 of Tumour Micro-environment
Bennewith KL, Erler JT, Giaccia AJ
(2010) John Wiley Publications ISBN:978-0-4707-4996-8
Critical steps in cancer metastasis: Chapter 3 of Abeloff’s Clinical Oncology
Erler JT, Giaccia AJ
(2008) Elsevier Publications
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